Investigating the role of the hypothalamic supraoptic nucleus in nociception in the rat |
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Authors: | Yang Jun Yang Yu Chen Jian-Min Liu Wen-Yan Lin Bao-Chen |
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Affiliation: | Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co. Ltd, Jiangmen, Guangdong, China. yj6676@yahoo.com |
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Abstract: | We investigated the role of the hypothalamic supraoptic nucleus (SON) in nociception in the rat. Electrical stimulation of the SON or microinjection of a small dose of L-glutamate sodium into the SON elevated the nociceptive threshold in a dose-dependent manner, while cauterization of the SON decreased the nociceptive threshold. Pituitary removal did not influence the antinociceptive effect of L-glutamate sodium in the SON. The data suggested that the neurons and not the nervous fibers in the SON played an important role in antinociception. |
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