Improving consensus contact prediction via server correlation reduction |
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| Authors: | Xin Gao Dongbo Bu Jinbo Xu Ming Li |
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| Institution: | (1) David R. Cheriton School of Computer Science, University of Waterloo, N2L3G1, Canada;(2) Institute of Computing Technology, Chinese Academy of Sciences, Beijing, 100080, PR China;(3) Toyota Technological Institute at Chicago, 1427 East 60th Street, Chicago, Illinois 60637, USA |
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| Abstract: | Background Protein inter-residue contacts play a crucial role in the determination and prediction of protein structures. Previous studies
on contact prediction indicate that although template-based consensus methods outperform sequence-based methods on targets
with typical templates, such consensus methods perform poorly on new fold targets. However, we find out that even for new
fold targets, the models generated by threading programs can contain many true contacts. The challenge is how to identify
them. |
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