Vitamin B3 confers resistance to sulfa drugs in Saccharomyces cerevisiae |
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Authors: | Kornfeld Olga Nichols Brian P |
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Institution: | Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA. |
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Abstract: | Sulfa drugs are ubiquitous antibiotics used to treat bacterial infections and diseases caused by eukaryotes, such as Pneumocystis carinii, the leading cause of pneumonia (PCP) in HIV patients. A daily regimen of sulfonamides and multivitamins including vitamin B3 is also recommended for persons with HIV. We show that exogenous vitamin B3 (nicotinate) confers resistance to sulfa drugs in Saccharomyces cerevisiae, a model for P. carinii. We propose a model of metabolic rerouting in which increased nicotinate leads to increased intracellular concentration of p-aminobenzoate, thus leading to sulfonamide resistance. |
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Keywords: | Nicotinate Sulfonamide resistance Sulfamethoxazole Sulfathiazole Folate |
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