Effects of dibutyryl cyclic GMP on rabbit pancreas secretion |
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Authors: | G.A.J. Kuijpers I.G.P. van Nooy J.J.H.H.M. De Pont S.L. Bonting |
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Affiliation: | Department of Biochemistry, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands |
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Abstract: | The isolated rabbit pancreas responds to the hormone cholecystokinin-pancreozymin and its C-terminal peptide with increases in protein secretion and in paracellular permeability. Dibutyryl cyclic GMP competitively inhibits these responses to the C-terminal octapeptide, but with different sensitivity. In low concentrations dibutyryl cyclic GMP lowers only the increase in the paracellular permeability, whereas in high concentrations it inhibits both the protein secretion and the permeability increase. The effect can be explained by assuming competition between dibutyryl cyclic GMP and the hormone at the level of the pancreozymin receptors. |
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Keywords: | dibutyryl cyclic GMP Protein secretion Pancreozymin Cholecystokinin (Rabbit pancreas) |
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