Effect of phenylethanolamine N-methyltransferase and dopamine-beta-hydroxylase inhibition on epinephrine levels in the brain. |
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| Authors: | A M Sauter J Y Lew Y Baba M Goldstein |
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| Institution: | Department of Psychiatry Neurochemistry Laboratories New York University Medical Center New York, New York 10016, USA |
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| Abstract: | The effects of phenylethanolamine N-methyltransferase (PNMT) and dopamine-β-hydroxylase (DβH) inhibition on the epinephrine content in specific regions of the brain were studied. SKF 64139, a potent PNMT inhibitor, is effective in lowering brain epinephrine levels. The time course of PNMT inhibition by SKF 64139 parallels the lowering of epinephrine levels in the brain. Diethyldithiocarbamate (DDC), a potent inhibitor of DβH, is effective in lowering norepinephrine and epinephrine levels and in elevating dopamine levels in the analyzed regions of the brain. The epinephrine levels in the brain appear to be under similar biosynthetic control as in the adrenal glands. |
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