Antimitogenic effect of Larrea divaricata Cav.: participation in arachidonate metabolism |
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| Affiliation: | 1. State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin, China Institute of Water Resources and Hydropower Research, Beijing 100048, PR China;2. Research Center on Soil and Water Conservation of the Ministry of Water Resources, Beijing 100048, PR China;3. State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, PR China;4. Xifeng soil and water conservation experimental station, Yellow River Conservancy Commission of the Ministry of Water Resources, PR China;1. Instituto de Biotecnología-Instituto de Ciencias Básicas, CONICET, Facultad de Ingeniería, Universidad Nacional de San Juan, Av. Libertador General San Martín 1109 (O), San Juan CP 5400, Argentina;2. Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, San Luis 5700, Argentina;3. ICYTAC-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina;4. Cátedra de Jardinería, Facultad de Agronomía, Universidad de Buenos Aires, Av. San Martín 4453, Buenos Aires 1417, Argentina;5. Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucumán, Fundación Miguel Lillo 251, Tucumán, Argentina;6. Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Avda. Joan XXIII s/n, Barcelona 08028, Spain;1. Department of Pharmacognosy, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey;2. Institute of Pharmaceutical Biology, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt/Main, Germany |
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| Abstract: | Aqueous extracts of the leaves of Larrea divaricata Cav. exert antimitogenic effects on tumor cells (BW 5147 murine immature T-lymphoma) and normal, stimulated lymphocytes. The effective concentration was four times smaller in the case of tumor cells than in the case of normal, stimulated lymphocytes. Inhibitor studies of arachidonate pathway suggest that the proliferative effect of the extract is due to the activation of lipoxygenase metabolism, while the inhibitory action could be a direct effect. |
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