A high resolution PIXE measurement for blood plasma ultrafiltrate |
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| Authors: | T Kupila-Rantala J T Dabek M Hyvönen-Dabek |
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| Institution: | (1) Department of Physics, University of Helsinki, P.O. Box 9, FIN-00014 Helsinki, Finland;(2) Department of Clinical Chemistry, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland |
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| Abstract: | A new technique for investigation of elemental concentrations in subfractions of blood plasma is presented. The method is
composed of the ultrafiltration of plasma in the presence of ethylenediaminetetraacetic acid (EDTA) and the measurement of
the elemental composition by proton-induced X-ray emission (PIXE). The blood samples were collected from both healthy persons
and patients suffering from breast cancer. The main emphasis in this study was on the determination of loosely bound copper
(Cu) in plasma subfractions containing substances with molecular mass under 10,000, but zinc (Zn) and iron (Fe) contents of
these fractions were also determined. The detection limits obtained with this method for Cu, Zn and Fe were ≈10 ppb (wet wt). |
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| Keywords: | Ultrafiltration PIXE copper blood plasma breast cancer |
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