Some potential anticancer palladium(II) complexes of 2,2'-bipyridine and amino acids |
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| Authors: | K H Puthraya T S Srivastava A J Amonkar M K Adwankar M P Chitnis |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111 Maragheh, Iran;2. Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy;3. Departament de Química, Universitat de les Illes Balears, Crta de Valldemossa km 7.5, 07122 Palma de Mallorca (Baleares), Spain;4. Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049–001 Lisboa, Portugal;5. Department of Chemistry, Baku State University, Z. Khalilov str. 23, AZ 1148 Baku, Azerbaijan;6. University of Tyumen, Volodarskogo Str. 6, 625003 Tyumen, Russian Federation;7. West-Siberian Interregional Scientific and Educational Center, Russian Federation;8. Innovation Center for Chemical and Pharmaceutical Technologies, Ural Federal University named after the First President of Russia B.N. Eltsin, Mira Str. 19, Ekaterinburg 620002, Russian Federation;1. Physics Department, Faculty of Science, Kafrelsheikh University, 33516 El Gaish Street, Kafr El Sheikh, Egypt;2. Chemistry Department, Faculty of Science, Kafrelsheikh University, 33516 El Gaish Street, Kafr El Sheikh, Egypt;1. Department of Chemistry, Guru Nanak Dev University, Amritsar 143 005, India;2. Departamento de Quimica Inorganica, Facultad de Farmacia, Universidad de Santiago, 15782 Santiago, Spain;3. Department of Chemistry, Keene State College, Keene, NH 03435-2001, USA |
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| Abstract: | Nine new palladium(II) complexes of the formula [Pd(bipy)(AA)]n+ (where bipy is 2,2'-bipyridine, AA is an anion of L-cysteine, L-aspartic acid, L-glutamic acid, L-methionine, L-histidine, L-arginine, L-phenylalanine, L-tyrosine, or L-tryptophan, and n = 0 or 1) have been synthesized by interaction of [Pd(bipy)Cl2] with an appropriate sodium salt of amino acid in water. These palladium(II) complexes have been characterized by chemical analysis and by visible, infrared, and 1H NMR spectroscopy. The modes of binding of amino acids in these palladium complexes have been ascertained by infrared and 1H NMR spectroscopy. The molar conductances of these complexes in water suggest that they are either nonelectrolytes or 1:1 electrolytes. These palladium complexes have shown growth inhibition against L1210 lymphoid leukemic, P388 lymphocytic leukemic, Sarcama 180, and Ehrlich ascites tumor cells. Some of these complexes show I.D.50 values comparable to or lower than cis-diamminedichloroplatinum(II). |
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