Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues |
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| Authors: | Dankwardt S M Martin R L Chan C S Van Wart H E Walker K A Delaet N G Robinson L A |
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| Institution: | Roche Bioscience, Inflammatory Diseases Unit, 3401 Hillview Ave, Palo Alto, CA 94304, USA. sharon.dankwardt@roche.com |
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| Abstract: | A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP). |
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