Excretion of 17-hydroxycorticosteroids under the effect of combined preparations containing separate progestagens: ethynodiol diacetate and chlormadinone

28 women were treated with .1 mg of mestranol + 3 mg of chlormadinone and 25 were treated with .1 mg of mestranol + 1 mg of ethynodiol diacetate. Examinations of the excretion of 17-corticosteroids in the urine were made and compared between the 2 groups. In the group treated with mestranol + chlormadinone here was no change in the excretion of 17-OHCS. The group of women treated with mestranol + ethynodiol diacetate showed a significant decrease of approximately 37%. The difference in the effects of these preparations is thought to be caused by their different chemical structure.