B-cell development and antigen receptor signalling |
| |
| Authors: | Turner M |
| |
| Affiliation: | Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. martin.turner@bbsrc.ac.uk |
| |
| Abstract: | B-cell development and function requires the products of the Vav family of genes. Vav proteins act as key components of the antigen receptor signal transduction machinery by integration of signals that control the cell cycle, differentiation and apoptosis. At the molecular level, Vav proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
