An Efficient,Optimized Synthesis of Fentanyl and Related Analogs |
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| Authors: | Carlos A. Valdez Roald N. Leif Brian P. Mayer |
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| Affiliation: | 1. Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, United States of America.; 2. Forensic Science Center, Lawrence Livermore National Laboratory, Livermore, California, United States of America.; Bangor University, United Kingdom, |
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| Abstract: | The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations leading to these powerful analgesics after optimization studies were carried out for each synthetic step. The general three-step strategy produced a panel of four fentanyls in excellent yields (73–78%) along with their more commonly encountered hydrochloride and citric acid salts. The following strategy offers the opportunity for the gram-scale, efficient production of this interesting class of opioid alkaloids. |
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