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Investigation of 6-[18F]-Fluoromaltose as a Novel PET Tracer for Imaging Bacterial Infection |
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| Authors: | Gayatri Gowrishankar Mohammad Namavari Erwan Benjamin Jouannot Aileen Hoehne Robert Reeves Jonathan Hardy Sanjiv Sam Gambhir |
| Institution: | 1. Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America.; 2. Sanofi R&D, Sanofi, Paris, France.; 3. Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America.; 4. Department of Bioengineering, Stanford University School of Medicine, Stanford, California, United States of America.; Banner Alzheimer''s Institute, United States of America, |
| Abstract: | Despite advances in the field of nuclear medicine, the imaging of bacterial infections has remained a challenge. The existing reagents suffer from poor sensitivity and specificity. In this study we investigate the potential of a novel PET (positron emission tomography) tracer that overcomes these limitations.Methods6-18F]-fluoromaltose was synthesized. Its behavior in vitro was evaluated in bacterial and mammalian cultures. Detailed pharmacokinetic and biodistribution profiles for the tracer were obtained from a murine model.Results6-18F]-fluoromaltose is taken up by multiple strains of pathogenic bacteria. It is not taken up by mammalian cancer cell lines. 6-18F]-fluoromaltose is retained in infected muscles in a murine model of bacterial myositis. It does not accumulate in inflamed tissue.ConclusionWe have shown that 6-18F]-fluoromaltose can be used to image bacterial infection in vivo with high specificity. We believe that this class of agents will have a significant impact on the clinical management of patients. |
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