Pleiotropic mutations within two yeast mitochondrial cytochrome genes block mRNA processing. |
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Authors: | G M Church P P Slonimski W Gilbert |
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Institution: | 1. Biological Laboratories Harvard University Cambridge, Massachusetts 02138 USA;2. Centre de Genetique Moleculaire du C.N.R.S. et Université Pierre et Marie Curie Gif-sur-Yvette, 91190 France |
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Abstract: | The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants seem to lack a functional trans-acting RNA required for the processing of both messengers. In contrast, the oxi-3 mutants may act by producing an activity that inhibits specific steps. |
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