Absence of hyaluronidase in cultured human skin fibroblasts. |
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| Authors: | B Arbogast J J Hopwood A Dorfman |
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| Affiliation: | Departments of Pediatrics and Biochemistry and the Joseph P. Kennedy, Jr. Mental Retardation Research Center Pritzker School of Medicine University of Chicago, Chicago, Illinois 60637 USA |
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| Abstract: | The in vitro degradation of [35S]chondroitin sulfate was investigated in human fibroblasts and rat liver. In rat liver, preparations of chondroitin sulfate were shown to be degraded by the concerted action of endoglycosidase and exoglycosidases. However, with human skin fibroblast preparations, hyaluronidase activity was not detected and chondroitin sulfate was degraded by exoglycosidase action. |
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