A comparison of C14-labeling patterns in deoxyribose and ribose in mammalian cells |
| |
| Authors: | HORECKER B L DOMAGK G HIATT H H |
| |
| Affiliation: | 1. LaMCoS-CNRS & LGCIE, INSA-Lyon, Universitité de Lyon, 20 avenue Albert Einstein, 69621, Villeurbanne cedex, France;2. LGCIE, INSA-Lyon, Université de Lyon, 20 avenue Albert Einstein, 69621, Villeurbanne cedex, France;3. Institut für Geophysik, Westfälische Wilhelms-Universität Münster, Corrensstraße 24, 48149, Münster, Germany;4. Chair for Nonlinear Analysis and Modelling, Fakultät für Mathematik, Universität Duisburg-Essen, Thea-Leymann Str. 9, 45127 Essen, Germany; Alexandru Ioan Cuza University of Iaşi, Department of Mathematics, Blvd. Carol I, no. 11, 700506 Iaşi, Romania; and Octav Mayer Institute of Mathematics of the Romanian Academy, Iaşi Branch, 700505 Iaşi, Germany;5. Head of Chair for Nonlinear Analysis and Modelling, Fakultät für Mathematik, Universität Duisburg-Essen, Mathematik-Carrée, Thea-Leymann-Straße 9, 45127 Essen, Germany |
| |
| Abstract: | Methods are described for the isolation and degradation of deoxyribose from deoxyribonucleic acid. In regenerating liver, ascites tumor, and HeLa cells the pattern of labeling in deoxyribose formed from specifically labeled glucose or ribose is similar to that found in ribose. Differences observed in the relative labeling of C-1 and C-2 of ribose and deoxyribose can be interpreted in terms of two pathways of ribose synthesis. However, in experiments with C-1 labeled glucose, C-5 of deoxyribose was heavily labeled, indicating a possible triose phosphate precursor. It is unlikely that acetaldehyde plays a significant role in the in vivo formation of deoxyribose. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
