The ERK cascade |
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Authors: | Hadara Rubinfeld Rony Seger |
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Institution: | (1) Department of Biological Regulation, The Weizmann Institute of Science, 76100 Rehovot, Israel;(2) Present address: Institute of Endocrinology, Chaim Sheba Medical Center, Tel-Hashomer, 52621 Ramat Gan, Israel |
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Abstract: | Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK) cascades is a common mechanism
of signal transduction in many cellular processes. Four such cascades have been elucidated thus far, and named according to
their MAPK tier component as the ERK1/2, JNK, p38MAPK, and ERK5 cascades. These cascades cooperate in transmitting various
extracellular signals, and thus control cellular processes such as proliferation, differentiation, development, stress response,
and apoptosis. Here we describe the classic ERK1/2 cascade, and concentrate mainly on the properties of MEK1/2 and ERK1/2,
including their mode of regulation and their role in various cellular processes and in oncogenesis. This cascade may serve
as a prototype of the other MAPK cascades, and the study of this cascade is likely to contribute to the understanding of mitogenic
and other processes in many cell lines and tissues. |
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Keywords: | MAPK ERK protein kinases signaling cascade |
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