A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage |
| |
Authors: | J K Juang H W Huang C M Chen H J Liu |
| |
Affiliation: | Institute of Life Science and National Tsing Hua University, Taiwan, R.O.C. |
| |
Abstract: | Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNA damage in vitro. It has two effective dosage ranges of approximate 0.5 and 20 microM, with about one-third the activity of 20 microM VM-26. |
| |
Keywords: | |
|
|