黏附分子CD24在肿瘤转移中作用

CD24属糖基磷脂酰肌醇锚蛋白。作为P-选择素配体的黏附分子,其可调节B细胞发育和神经发生。研究显示,CD24高表达在多种肿瘤细胞表面,参与肿瘤的发生发展。已通过体外试验和动物模型证实CD24对多种肿瘤生长和转移相关的肿瘤细胞特性具有调节作用;结合人肿瘤组织研究显示,CD24和乳腺癌、前列腺癌、胰腺癌及肝内胆管癌等肿瘤患者的生存率及预后密切相关。因此,以CD24为靶向的肿瘤诊断和治疗有着诱人的临床应用前景。

The Role of Adhesion Molecule CD24 in Tumor Metastasis

Glycosylphosphatidylinositol-anchored membrane protein CD24 is a ligand of P-selectin and plays a role in B-cell development and neurogenesis. Over the last years, a large body of literature has implicated CD24 overexpression in tumorigenesis and progression. Some investigator showed that ectopic CD24 expression could be sufficient to promote tumor growth and metastasis in experimental animals. Enhanced CD24 expression correlating with prognosis, survival rate and clinical pathological parameter of tumor patients has been reported for a number of types of cancer, including renal cell carcinoma, small cell lung carcinoma, nasopharyngeal carcinoma, pancreatic carcinoma and neural tumors. Therefore, these investigations will help us to elucidate the molecular mechanisms of tumor progression. And furthermore, it could lead to the development of anti-cancer drugs and new therapeutic approaches.