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Recurring genomic structural variation leads to clonal instability and loss of productivity
Authors:Arpan A Bandyopadhyay  Sofie A O’Brien  Liang Zhao  Hsu-Yuan Fu  Nandita Vishwanathan  Wei-Shou Hu
Institution:1. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota

Arpan A. Bandyopadhyay and Sofie A. O’Brien contributed equally to this work.;2. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota;3. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota

Present address: MycoMagic Co. Ltd, New Taipei City, Taiwan;4. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota

Present address: Merck Serono, Corsier-sur-Vevey, Switzerland

Abstract:
Keywords:cell stability  CGH  Chinese hamster ovary cells  genome instability  karyotype
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