Tolazoline antagonises ketamine–xylazine anaesthesia in an endangered Black buck (<Emphasis Type="Italic">Antilope cervicapra</Emphasis>) |
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| Authors: | Sadanand D Sontakke Govindaswamy Umapathy Manoj S Patil Sisinthy Shivaji |
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| Institution: | (1) Laboratory for the Conservation of Endangered Species (LaCONES), Centre for Cellular and Molecular Biology Annexe-I, Attapur Ring Road, Hyderabad, 500 048, India;(2) Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India |
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| Abstract: | Seventy-seven anaesthetic events were carried out in 22 captive adult Black bucks (Antilope cervicapra) of either sex with a combination of 2 mg kg−1 ketamine hydrochloride with 0.25 mg kg−1 xylazine hydrochloride using a dart delivered from a blowpipe. Randomised anaesthetised animals received an intravenous injection
of either yohimbine hydrochloride (0.125 or 0.25 mg kg−1) or tolazoline hydrochloride (1 or 2 mg kg−1) after 30–40 min of anaesthesia to antagonise the anaesthetic effects. Ketamine–xylazine induced smooth, rapid and reliable
anaesthesia within 5–7 min of darting with no clinical adverse effects and causalities during or post-anaesthesia. Yohimbine
failed to antagonise the anaesthetic effects of ketamine–xylazine in the Black buck. On the other hand, tolazoline was found
to be very effective in hastening recovery in dose-dependent manner within 0.5–1.5 min. This study documents the first report
of ketamine–xylazine anaesthesia and its antagonism by tolazoline in captive Black buck. |
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| Keywords: | Antelope Chemical restraint Immobilisation Alpha2-adrenergic antagonist |
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