Stimulation of 45Ca efflux from rat lacrimal gland slices by carbachol and epinephrine |
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Authors: | R J Parod J W Putney |
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Affiliation: | Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA |
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Abstract: | The effects of carbachol (10?5M) and epinephrine (10?5M) on efflux of 45Ca from rat exorbital lacrimal gland slices were examined. Both carbachol and epinephrine stimulated a transient release of 45Ca from the tissue. The quantity of Ca released was estimated to be of the order of 0.5 μmol/g. Release of 45Ca by one agonist prevented subsequent release of 45Ca by a different agonist. These data support the hypothesis put forth previously that in the lacrimal gland muscarinic or α-adrenergic receptor activation causes a transient increase in membrane permeability to K by triggering the release of a sizable intracellular pool of Ca common to both receptors. |
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