A risk-associated single nucleotide polymorphism of <Emphasis Type="Italic">SMAD7</Emphasis> is common to colorectal,gastric, and lung cancers in a Han Chinese population |
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Authors: | Xin?Li Xue-xi?Yang Ni-ya?Hu Jing-zhe?Sun Fen-xia?Li Email author" target="_blank">Ming?LiEmail author |
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Institution: | (1) School of Biotechnology, Southern Medical University, Guangzhou, 510515, People’s Republic of China;(2) Department of Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China;(3) Da An Gene Co.,Ltd. of Sun Yat-sen University, Guangzhou, 510665, People’s Republic of China; |
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Abstract: | SMAD7 has been demonstrated to antagonize TGF-β-mediated fibrosis, carcinogenesis, and inflammation. Two previous genome-wide
association studies identified three single nucleotide polymorphisms (SNPs) (rs4939827, rs12953717 and rs4464148) in SMAD7 to be associated with colorectal cancer in a Western population. We conducted the first case–control study in a Han Chinese
population to explore the associations between these three SNPs and colorectal, gastric, and lung cancers. Of the three SNPs,
only rs12953717 was strongly associated with the three types of cancer, fitting the overdominant model. Compared with the
CC/TT (CC combined with TT) genotype, the adjusted odds ratios for the CT genotype were 2.002 (95% CI, 1.250–3.207, P = 0.004), 1.678 (95% CI, 1.048–2.689, P = 0.031), 3.825 (95% CI, 2.310–6.335, P < 1 × 10−4), and 2.294 (95% CI, 1.537–3.343, P < 1 × 10−4), respectively, for colorectal, gastric, lung, and combined cancers. These outcomes suggest that rs12953717 is a common risk
marker of these three types of cancer in the Han Chinese. |
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