A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of mometasone furoate in human plasma |
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Authors: | Sahasranaman Srikumar Tang Yufei Biniasz Diana Hochhaus Guenther |
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Affiliation: | Department of Pharmaceutics, College of Pharmacy, PO 100494, University of Florida, Gainesville, FL 32610, USA. |
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Abstract: | A robust, rapid, selective and sensitive liquid chromatography-negative atmospheric pressure chemical ionization (LC-(APCI(-))-MS-MS) method has been developed for the quantification of mometasone furoate (MF) in human plasma utilizing a solid-phase extraction clean-up step and 13C-fluticasone propionate as internal standard. The intra- and inter-day coefficients of variation were < or = 15% and the lower limit of quantification (LLOQ) was 15 pg/ml. This method is ideally suited for pharmacokinetic investigations of low MF levels following inhalation of MF. |
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Keywords: | HPLC–MS–MS Glucocorticoid Drug analysis Mometasone furoate Liquid chromatography–tandem mass spectrometry |
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