DNA damage induces nuclear translocation of parkin |
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Authors: | Shyan-Yuan Kao |
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Institution: | (1) Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, 02114 Boston, MA, USA |
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Abstract: | Parkinson's disease (PD) is the second most common form of human degenerative disorder. Mutation of parkin is one of the most prevalent causes of autosomal recessive PD. Parkin is an E3 ubiquitin ligase that acts on a variety of
substrates, resulting in polyubiquitination and degradation by the proteasome or monoubiquitination and regulation of biological
activity. However, the cellular functions of parkin that relate to its pathological involvement in PD are not well understood.
Here I show that parkin translocates into nucleus upon DNA damage. Nuclear translocation of parkin appears to be required
to promote DNA repair. These findings suggest that DNA damage induces nuclear translocation of parkin leading to the PCNA
interaction and possibly other nuclear proteins involved in DNA repair. These results suggest that parkin promotes DNA repair
and protects against genotoxicity, and implicate DNA damage as a potential pathogenic mechanism in parkinsonism. |
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