Con A induced suppressor cells: suppression with I region incompatibility. |
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| Authors: | E Dugan J E Niederhuber J A Frelinger L Mayo D C Shreffler |
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| Affiliation: | Departments of Microbiology, Human Genetics and Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109 U.S.A. |
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| Abstract: | Allogeneic Con A induced suppressor cells differing in the I and S region but not H-2K or H-2D regions were as efficient as syngeneic cells in suppressing the secondary IgM and IgG response to burro erythrocytes. Con A activated suppressor cells were not sensitive to anti-Ia serum and complement. However, if the spleen cell population was treated with anti-Ia serum and complement before stimulation with Con A, suppressor cells were not generated. |
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