Mast cell degranulating peptide forms voltage gated and cation-selective channels in lipid bilayers |
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| Authors: | T Ide T Taguchi T Morita M Sato K Ikenaka S Aimoto T Kondo H Hojo M Kasai K Mikoshiba |
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| Affiliation: | Department of Biophysical Engineering, Faculty of Engineering Science, Osaka University, Japan. |
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| Abstract: | Mast cell degranulating peptide, a toxin of bee venom, is a polypeptide composed of 22 amino acids. Exposure of the asolectin bilayer to the peptide results in the formation of channels that are more permeable to K+ than Cl-. These channels are activated when the voltage of the cis side, to which the peptide is added, is made positive. |
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