| miRNA的生物形成及调控基因表达机制 |
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| 引用本文： | 郑永霞,焦炳华.miRNA的生物形成及调控基因表达机制[J].生命的化学,2010(6). |
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| 作者姓名： | 郑永霞 焦炳华 |
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| 作者单位： | 第二军医大学基础部生物化学与分子生物学教研室;嘉兴学院医学院生物化学教研室; |
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| 摘 要： | 微RNA(microRNA,miRNA)通过调节靶基因的表达水平影响细胞分化、增殖、凋亡等特性,在生物的生长发育和疾病发生发展中发挥重要的作用。将miRNA用于基因功能研究,药物靶点验证,基因治疗等领域有非常好的前景。揭示miRNA的生成和加工过程以及miRNA调节靶基因基因表达水平的作用机制对于阐述miRNA在生理病理过程中的作用有重要意义。因此,本文对miRNA的发生,成熟以及作用机制的研究进展作综述。
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| 关 键 词： | miRNA 基因簇 组织特异性 RNA编辑 |
Biogenesis of microRNA and mechanism of the regulation of gene expression |
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| Yong-Xia Zheng,Bing-Hua Jiao.Biogenesis of microRNA and mechanism of the regulation of gene expression[J].Chemistry of Life,2010(6). |
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| Authors: | Yong-Xia Zheng Bing-Hua Jiao |
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| Institution: | Yong-Xia Zheng1,2,Bing-Hua Jiao11Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China,2Medical College,Jiaxing University,Jiaxing 314001,Chin |
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| Abstract: | MiRNAs regulate target gene expression and influence diverse biological functions,such as differentiation,apoptosis,and cell proliferation.They play important roles during normal growth and development of organism and in the development of disease.They also are expected to be used in gene function studies,drug target authentication,even for gene therapy.It is important to reveal the mechanism of biogenesis,maturation and the regulation of target genes in the set physiological and pathological processes.Ther... |
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| Keywords: | microRNA gene cluster tissue-specific miRNA RNA editing |
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