| Id-1在恶性肿瘤发生中的作用及其机制 |
| |
| 引用本文： | 郭斌,张成梅,刘少华.Id-1在恶性肿瘤发生中的作用及其机制[J].生命科学,2010(5):401-404. |
| |
| 作者姓名： | 郭斌 张成梅 刘少华 |
| |
| 作者单位： | 山东大学齐鲁医院口腔颌面外科;山东大学动物实验中心; |
| |
| 基金项目： | 国家自然科学基金项目(30672339) |
| |
| 摘 要： | 分化抑制因子-1(inhibitor of differentiation protein 1,Id-1)是Id转录调节蛋白家族成员之一,属于螺旋-环-螺旋蛋白超家族成员。早期对Id-1的研究认为其主要作用是负向调节正常细胞的分化。近年来研究表明,Id-1在多种肿瘤中过表达并通过多条信号通路促进肿瘤的发生,现就Id-1在肿瘤发生中的作用及其作用机制作一综述。
|
| 关 键 词： | 分化抑制因子-1 肿瘤发生 机制 |
The roles and mechanisms of Id-1 in tumorigenesis |
| |
| GUO Bin,ZHANG Cheng-mei,LIU Shao-hua.The roles and mechanisms of Id-1 in tumorigenesis[J].Chinese Bulletin of Life Sciences,2010(5):401-404. |
| |
| Authors: | GUO Bin ZHANG Cheng-mei LIU Shao-hua |
| |
| Institution: | GUO Bin1,ZHANG Cheng-mei2,LIU Shao-hua1 (1 Department of Oral and Maxillofacial Surgery,Qilu Hospital,Shandong University,Jinan 250012,China,2 Experi-mental Animal Center,China) |
| |
| Abstract: | Id-1 (inhibitor of differentiation protein 1) is a member of Id protein family, belongs to the helix-loop-helix proteins superfamily. Early studies have shown that Id-1 mainly acted as a negative regulator of cell differetiation. Recently, Id-1 overexpression has been found in plenty of cancers by promoting tumorigenesis through several signal pathways. This review will focus on the roles of Id-1 in tumorigenesis and its relative mechanisms. |
| |
| Keywords: | inhibitor of differentiation protein 1 tumorigenesis mechanism |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
