| B型酪氨酸激酶受体的轴浆转运 |
| |
| 引用本文： | 张雯雯,孙崇璟,赵玲,陈哲宇. B型酪氨酸激酶受体的轴浆转运[J]. 生命的化学, 2010, 0(6) |
| |
| 作者姓名： | 张雯雯 孙崇璟 赵玲 陈哲宇 |
| |
| 作者单位： | 山东大学医学院临床六年制;山东大学医学院神经生物研究所; |
| |
| 基金项目： | 山东大学自主创新基金自然科学类自由探索专项课题(No.2009TS126);山东大学2008年度国家大学生创新性实验计划项目(No.187)资助 |
| |
| 摘 要： | 脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)在发育及成熟的中枢神经系统(central nervoussystem,CNS)中起到举足轻重的调节作用,而其中绝大部分作用由其B型酪氨酸激酶受体(tyrosine kinase receptortype B,TrkB)介导,因此TrkB在神经元中的轴浆转运过程显得尤为重要。本文从动力蛋白、潜在调节分子、细胞骨架蛋白等方面对TrkB轴浆转运分子机制的研究进展进行综述,并就其进一步研究提出一系列的问题与展望。
|
| 关 键 词： | 脑源性神经营养因子 受体 TrkB 轴浆转运 |
Progress and prospect on the axoplasmic transport of TrkB |
| |
| Wen-Wen Zhang,Chong-Jing Sun,Ling Zhao,Zhe-Yu ChenSchool of Medicine,Sh,ong University,Jinan ,China. Progress and prospect on the axoplasmic transport of TrkB[J]. Chemistry of Life, 2010, 0(6) |
| |
| Authors: | Wen-Wen Zhang Chong-Jing Sun Ling Zhao Zhe-Yu ChenSchool of Medicine Sh ong University Jinan China |
| |
| Affiliation: | Wen-Wen Zhang1,Chong-Jing Sun1,Ling Zhao2,Zhe-Yu Chen21School of Medicine,Shandong University,Jinan 250012,China,2Department of Neurobiology,School of Medicine,Chin |
| |
| Abstract: | Brain derived neurotrophic factor(BDNF) plays many significant roles in developing and mature central nervous system(CNS),most of which are mediated by the tyrosine kinase receptor type 2(TrkB) receptors.Thus the axoplasmic transport of TrkB is particularly important.In this review,we introduced the latest findings in the molecular mechanisms of axoplasmic transport of TrkB in terms of motor proteins,potential regulators and correlative cell skeletal proteins which are proved to be involved in this process,... |
| |
| Keywords: | axonal transport brain derived neurotrophic factor(BDNF) receptor TrkB |
| 本文献已被 CNKI 等数据库收录！ |
|
