| 胰高血糖素样肽1:阿尔茨海默病治疗新策略 |
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| 作者姓名： | Wang XH Yang W Qi JS |
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| 作者单位： | 山西医科大学生理学系;细胞生理学省部共建教育部重点实验室; |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.30840085); the Open Research Fund of the Key Laboratory of Shanxi Province,China(No.2009011059-8); the Natural Science Foundation of Shanxi Province,China(No.2010011049-3); the Dean's Fund of the Co-constructing Key Laboratory of Cellular Physiology,Ministry of Education,Shanxi Medical University(2010-07); the Science and Technology Fund of Taiyuan City,China(No.100115168) |
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| 摘 要： | 2型糖尿病(type2diabetes mellitus,T2DM)与阿尔茨海默病(Alzheimer’s disease,AD)的病理生理过程具有密切的相关性。人们正在逐步深入研究治疗T2DM的最新药物——胰高血糖素样肽1(glucagon-likepe ptide1,GLP-1)的神经保护作用,并大胆地提出了利用GLP-1治疗AD的设想。本文对T2DM与AD的发病相关性、GLP-1的合成与分泌、GLP-1受体的中枢分布及其生理效应,特别是GLP-1与AD治疗策略相关的研究进展作一综述。
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| 关 键 词： | 胰高血糖素样肽1 神经保护 阿尔茨海默病 2型糖尿病 β-淀粉样蛋白 |
Glucagon-like peptide 1: a novel therapeutic strategy for Alzheimer's disease |
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| Wang XH,Yang W,Qi JS.Glucagon-like peptide 1: a novel therapeutic strategy for Alzheimer's disease[J].Acta Physiologica Sinica,2010,62(5):398-406. |
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| Authors: | Wang Xiao-Hui Yang Wei Qi Jin-Shun |
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| Institution: | WANG Xiao-Hui,YANG Wei,QI Jin-Shun Department of Physiology,Key Laboratory for Cellular Physiology of Ministry of Education,Shanxi Medical University,Taiyuan 030001,China |
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| Abstract: | There is a close correlation between type 2 diabetes mellitus(T2DM) and Alzheimer's disease(AD) in the course of pathophysiological processes.The neuroprotective action of glucagon-like peptide 1(GLP-1),a latest drug for clinical treatment of T2DM,is being more deeply investigated at present,and a novel therapeutic strategy for AD with GLP-1 has been proposed boldly.This review mainly discussed the correlation of pathogenesis between T2DM and AD,the synthesis and secretion of GLP-1,the distribution and phys... |
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