| ADAMTS-7,血管重塑中的新靶点(英文) |
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| 引用本文： | 王利,王宪,孔炜.ADAMTS-7,血管重塑中的新靶点(英文)[J].生理学报,2010(4). |
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| 作者姓名： | 王利 王宪 孔炜 |
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| 作者单位： | 北京大学基础医学院生理与病理生理学系分子心血管教育部重点实验室; |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.30670849,30870993); the Natural Science Foundation of Beijing,China(No.7072039); the “New Century Excellent Talents in Universities” Program from the Ministry of Education of China |
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| 摘 要： | 血管重塑是动脉粥样硬化和血管再狭窄发病中的一个重要的病理生理学过程。越来越多的证据表明,具有降解细胞外基质能力的酶在血管重塑中发挥着重要的作用。含I型血小板反应蛋白的解聚素和金属蛋白酶(a disintegrin and metalloproteinase with thrombospondin motifs,ADAMTS)家族是一类最近被克隆的金属蛋白酶家族,该家族成员同样具备降解细胞外基质的能力。ADAMTS家族由19个家族成员组成,参与了一系列的正常生理学功能,如发育、血管新生和凝血等。而ADAMTS家族成员的异常表达通常会引发各种疾病,如关节炎、肿瘤、凝血功能障碍性紫癜。本文从ADAMTS家族第七个成员——ADAMTS-7的结构、组织分布、调控、尤其是通过其底物软骨寡聚基质蛋白(cartilage oligomeric matrix protein,COMP)精细调控血管稳态几个方面综述了其在血管重塑中作用的最新研究进展。
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| 关 键 词： | ADAMTS-7 软骨寡聚基质蛋白 血管平滑肌 迁移 增殖 |
ADAMTS-7,a novel proteolytic culprit in vascular remodeling |
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| WANG Li,WANG Xian,KONG Wei.ADAMTS-7,a novel proteolytic culprit in vascular remodeling[J].Acta Physiologica Sinica,2010(4). |
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| Authors: | WANG Li WANG Xian KONG Wei |
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| Institution: | WANG Li,WANG Xian,KONG Wei Department of Physiology and Pathophysiology,Key Laboratory of Molecular Cardiovascular Science of Ministry of Education,Beijing 100191,China |
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| Abstract: | Vascular remodeling is being recognized as a fundamental process during atherosclerosis and restenosis.Cumulative studies have demonstrated that extracellular matrix(ECM) degrading enzymes play a critical role during vascular remodeling.A disintegrin and metalloproteinase with thrombospondin motifs(ADAMTS) family is a recently identified metalloproteinase family which also has capacity to degrade ECM.ADAMTS family consists of 19 members and has been linked to a variety of physiological processes including d... |
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| Keywords: | ADAMTS-7 COMP vascular smooth muscle migration proliferation |
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