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IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population |
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| Authors: | Ludovica Segat Daiana Bevilacqua Michele Boniotto Luiz C Arraes Paulo R de Souza Josè L de Lima Filho Sergio Crovella |
| Institution: | (1) Department of Reproductive and Developmental Sciences, University of Trieste, Via dell’Istria 65/1, Trieste, 34137, Italy;(2) Genetic Service, Children’s Hospital Burlo Garofolo, Trieste, Italy;(3) Instituto Materno Infantil do Pernambuco, Recife, Brazil;(4) Laboratorio de Imunopatologia Keizo Azami, Universitade Federal do Pernambuco, Recife, Brazil |
| Abstract: | In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the −607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism. |
| Keywords: | IL-18 HIV-1 infection Brazilian children Promoter polymorphism Single-tube allele-specific PCR |
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