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A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis |
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| Authors: | Chung Yu-Ming Chang Fang-Rong Tseng Tseng-Fu Hwang Tsong-Long Chen Lei-Chin Wu Shou-Fang Lee Chia-Lin Lin Zu-Yau Chuang Li-Yeh Su Jinu-Huang Wu Yang-Chang |
| Institution: | a Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan b Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan c Department of Medical Nutrition, College of Medicine, I-Shou University, Kaohsiung 840, Taiwan d General Clinical Research Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan e Department of Chemical Engineering, College of Science and Engineering, I-Shou University, Kaohsiung 840, Taiwan f Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan g Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan h Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan i Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 40402, Taiwan j Department of Obstetrics and Gynecology, Kaohsiung Medical University, Kaohsiung 807, Taiwan |
| Abstract: | A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC50 value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC50 values of 0.12 and 0.20 μg/mL, respectively. |
| Keywords: | Aristolochia manshuriensis Aristopyridinone A Aristolamide II Phenanthrene Anti-inflammatory Human neutrophils Superoxide anion Elastase release |
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