New perspectives on mitochondrial morphology in cell function |
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Authors: | Brocard Jacques B Rintoul Gordon L Reynolds Ian J |
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Affiliation: | Department of Pharmacology, School of Medicine, University of Pittsburgh, PA 15261, Pittsburgh, USA. jbrocard@cea.fr |
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Abstract: | Mitochondria are a node of integration for intracellular signaling pathways and their morphology changes seem to be tightly associated with their function. New data show that morphology is one of the parameters involved in mitochondria's choice between promoting cell death and protecting cells against general metabolic jeopardy. |
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Keywords: | Excitotoxicity Calcium signaling Mitochondrial fission/fusion |
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