The role of stress proteins HSP70 and the adrenergic system in different resistance to myocardial infarction of August and Wistar genetic rat strains] |
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| Authors: | M G Pshennikova L M Belkina L Iu Bakhtina L A Ba?da E V Popkova I Iu Malyshev |
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| Institution: | Institute of General Pathology and Pathophysiology, Russian Acad. Med. Sci., Moscow, 125315, Baltiyskaya St., 8, Russia. |
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| Abstract: | A lesser resistance against myocardial infarction (MI) in the Wistar rats as compared with the August rats was found to be combined with a greater stress-response and activation of the heart sympathetic regulation in the former rats. In the Wistar rats and not in August rats, an activation of hypothalamic noradrenaline (NA) system occurs as well as a greater "output" of the NA from sympathetic terminals in the myocardium. Accumulation of the HSP 70 stress-proteins in IM in the myocardium is nearly 2-2.5-fold lesser in the Wistar rats. Thereupon, different resistance against the IM in Wistar and August rats seems to be due to a genetically determine differences in intensity of the stress-response, activation of the heart sympathetic regulation in the IM, and production of the HSP 70 protective stress-proteins in the myocardium. |
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