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A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists |
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| Authors: | Dordal Alberto Lipkin Mike Macritchie Jackie Mas Josep Port Adriana Rose Sally Salgado Leonardo Savic Vladimir Schmidt Wolfgang Serafini Maria Teresa Spearing William Torrens Antoni Yeste Sandra |
| Affiliation: | Laboratorios Dr Esteve S.A. Av.Mare de Déu de Montserrat, Barcelona, Spain. |
| Abstract: | The metabolic stability of benzoxazinone derivatives, a potent series of NPY Y5 antagonists, has been investigated. This study resulted in the identification of the structural moieties prone to metabolic transformations and which strongly influenced the in vitro half-life. This provides opportunities to optimize the structure of this new class of NPY Y5 antagonists. |
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