| 14型肺炎球菌荚膜多糖-破伤风类毒素结合疫苗的研制 |
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| 引用本文： | 张萍,王欣茹,侯亚莉,张新庄,杜琳,谢贵林. 14型肺炎球菌荚膜多糖-破伤风类毒素结合疫苗的研制[J]. 微生物学免疫学进展, 2007, 35(1): 1-4 |
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| 作者姓名： | 张萍 王欣茹 侯亚莉 张新庄 杜琳 谢贵林 |
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| 作者单位： | 兰州生物制品研究所,兰州,730046 |
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| 摘 要： | 将14型肺炎球菌的荚膜多糖(PS)与破伤风类毒素(TT)通过化学方法结合,制备成多糖-蛋白结合疫苗(PS14-TT)。用该结合疫苗免疫小鼠,在小鼠体内产生了高滴度的PS-IgG抗体和TT-IgG抗体,且再次注射后有加强应答效应,表明制备的结合疫苗保留了完好的抗原性,具有胸腺依赖性抗原的特性。
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| 关 键 词： | 肺炎球菌 荚膜多糖 破伤风类毒素 结合疫苗 |
| 文章编号： | 1005-5673（2007）01-0001-04 |
| 收稿时间： | 2006-08-29 |
| 修稿时间： | 2006-10-27 |
Preparation of a conjugate vaccine composed of pneumococcus type 14 capsular polysaccharide bound to TT |
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| ZHANG Ping, WANG Xin-ru, HOU Ya-li,et al.. Preparation of a conjugate vaccine composed of pneumococcus type 14 capsular polysaccharide bound to TT[J]. Progress In Microbiology and Immunology, 2007, 35(1): 1-4 |
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| Authors: | ZHANG Ping WANG Xin-ru HOU Ya-li et al. |
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| Affiliation: | Lanzhou Institute of Biological Products, Lanzhou 730046, China |
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| Abstract: | The capsular polysaccharide of pneumococcus type 14 was bound to TT in order to prepare a conjugate vaccine.It showed that anti-PS14 IgG and anti-TT IgG antibodies could be elicited at a higher level in the mice when immunized by PS14-TT.It also showed the boosted responses when subcutaneously injected with the same preparation.The results indicate that the conjugate vaccine maintain the good antigenicity and the characters related to T cell dependent antigens. |
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| Keywords: | Pneumococcus Capsular polysaccharide TT Conjugate vaccine |
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