Synthesis and enzymatic characterization of P1-thio-P2-oxo trideoxynucleoside diphosphates having AZT, FdU, or dT at the 3'-position |
| |
Authors: | Otvös László Bajor Zoltán Kraicsovits Ferenc Sági Gyula Tegyey Zsuzsanna |
| |
Affiliation: | Chemical Research Center, Institute of Chemistry, Hungarian Academy of Sciences, Budapest. |
| |
Abstract: | Model compounds for oligonucleotide-prodrugs, P1-thio-P2-oxo-trideoxyribonucleoside diphosphates: d[G(s)C(o)X] and d[T(s)A(o)X] (X = AZT, FdU or dT) have been prepared, and their hydrolyses by snake venom phosphodiesterase and nuclease S1 are described. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|