Genealogical trees, coalescent theory and the analysis of genetic polymorphisms |
| |
Authors: | Rosenberg Noah A Nordborg Magnus |
| |
Affiliation: | Program in Molecular and Computational Biology, University of Southern California, 835 West 37th Street, SHS172, Los Angeles, California 90089-1340, USA. |
| |
Abstract: | Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|