Habitual exercise induced resistance to oxidative stress |
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| Authors: | Nakatani Koji Komatsu Masaharu Kato Toyohiro Yamanaka Takao Takekura Hiroaki Wagatsuma Akira Aoyama Kohji Xu Baohui Hirano Takeshi Kasai Hiroshi Ando Seiichi Takeuchi Toru |
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| Affiliation: | a Department of Physiological Sciences, National Institute of Fitness and Sports, Kanoya, Kagoshima, Japanb Department of Environmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japanc Graduate School of Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, Japand Department of Environmental Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japane Department of Fisheries Science, Kagoshima University, Shimoarata, Kagoshima, Japan |
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| Abstract: | We investigated whether habitual exercise (HE) modulates levels of oxidative DNA damage and responsiveness to oxidative stress induced by renal carcinogen Fe-nitrilotriacetic acid (Fe-NTA). During a ten week protocol, two groups of rats either remained sedentary or underwent swimming for 15-60 min per day, 5 days per week, with or without a weight equivalent to 5% of their body weight. Then we injected Fe-NTA and sacrificed the rats 1 h after the injection. We determined the activity of superoxide dismutase (SOD) in diaphragm and kidney, evaluated levels of 8-hydroxydeoxyguanosine (8OHdG), catalase, and glutathione peroxidase, and assayed OGG1 protein levels in kidney. SOD activity in the diaphragm and kidney was increased in HE rats. By itself, HE had no effect on the level of 8OHdG, but it did significantly suppress induction of 8OHdG by Fe-NTA, and the amount of suppression correlated with intensity of exercise. These results suggest that HE induces resistance to oxidative stress and, at least at the initiation stage, inhibits carcinogenesis. |
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| Keywords: | Exercise Fe-nitrilotriacetic acid 8-hydroxydeoxyguanosine OGG1 superoxide dismutase swimming |
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