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| 北方汉族人群白细胞介素-6基因-572C/G单核苷酸多态性与冠心病的相关性研究 | |
| 引用本文： | 梁振洋,张效林,孙莹,冯雪瑶,白净,闫承慧,康建,韩雅玲. 北方汉族人群白细胞介素-6基因-572C/G单核苷酸多态性与冠心病的相关性研究[J]. 现代生物医学进展, 2010, 10(24) |
| 作者姓名： | 梁振洋 张效林 孙莹 冯雪瑶 白净 闫承慧 康建 韩雅玲 |
| 作者单位： | 1. 第四军医大学西京医院心内科,陕西,西安,710061;沈阳军区总医院心内科,辽宁,沈阳,110016 2. 沈阳军区总医院心内科,辽宁,沈阳,110016 3. 辽宁医学院,辽宁,锦州,121001 4. 大连医科大学,辽宁,大连,116044 5. 第四军医大学西京医院心内科,陕西,西安,710061 |
| 基金项目： | 全军医学科学技术研究十一五计划课题项目(06G021) |
| 摘 要： | 目的:探讨中国北方汉族人群中白细胞介素-6(IL-6)基因启动子区-572C/G单核苷酸多态性与冠心病的关系。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测434例冠心病(冠心病组)患者和417名非冠心病人(对照组)的IL-6基因型,探讨-572C/G单核苷酸多态与冠心病的关系。结果:IL-6基因-572C/G多态位点的CC、CG和GG基因型在冠心病组中分别为59.68%、37.09%、3.23%,等位基因频率C和G分别为78.23%、21.77%;在健康成年者中基因型分别为67.87%、30.22%、1.92%,等位基因频率C和G分别为82.97%、17.03%。IL-6基因-572C/G位点多态性在两组人群中的分布差异存在显著性(P<0.05);经Logsitic回归校正性别、年龄、体重指数、高血压病、糖尿病、高胆固醇血症及吸烟等冠心病易患因素后,IL-6基因-572C/G单核苷酸多态是冠心病发病的独立的危险因素(P<0.05);等位基因频率的相对风险分析发现,G等位基因携带者患冠心病的风险是C等位基因的1.356倍〔OR=1.356,95%CI=1.0648～1.7279〕。... |
| 关 键 词： | 冠状动脉疾病 白细胞介素-6 启动子 基因多态性 |
Association of Interleukin-6 Gene-572C/G Single Nucleotide Polymorphism with Coronary Artery Disease in Han Population of North China |
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| LIANG Zhen-yang,ZHANG Xiao-lin,SUN Ying,FENG Xue-yao,BAI Jin,YAN Cheng-hui,KANG Jian,HAN Ya-ling. Association of Interleukin-6 Gene-572C/G Single Nucleotide Polymorphism with Coronary Artery Disease in Han Population of North China[J]. Progress in Modern Biomedicine, 2010, 10(24) | |
| Authors: | LIANG Zhen-yang ZHANG Xiao-lin SUN Ying FENG Xue-yao BAI Jin YAN Cheng-hui KANG Jian HAN Ya-ling |
| Affiliation: | LIANG Zhen-yang1,2,ZHANG Xiao-lin2,SUN Ying3,FENG Xue-yao4,BAI Jing1,YAN Cheng-hui2,KANG Jian2,HAN Ya-ling2(1 Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an,Shanxi,710061,China,2 Department of Cardiology,General Hospital of Shenyang Military Command,Shenyang,Liaoning,110016,3 Liaoning Medical University,Jinzhou,121001,4 Dalian Medical University,Dalian,116044,China) |
| Abstract: | Objective: To investigate the relationship between the Interleukin-6(IL-6) gene promoter region-572C / G single nu-cleotide polymorphism and coronary artery disease in Han population of North China.Methods: Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was used to detect the IL-6 genotype in 434 cases of coronary artery disease(CAD) patients and 417 non-coronary artery disease(control group) and the relationship between-572C/G single nucleotide polymorphism and coronary... |
| Keywords: | Coronary artery disease Interleukin-6 promoter gene polymorphism |
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