| 曲美他嗪人血浆蛋白结合率的测定 |
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| 引用本文： | 吕江,祁英杰,毕开顺,果德安,陈晓辉.曲美他嗪人血浆蛋白结合率的测定[J].现代生物医学进展,2010,10(24). |
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| 作者姓名： | 吕江 祁英杰 毕开顺 果德安 陈晓辉 |
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| 作者单位： | 1. 沈阳药科大学药学院,辽宁,沈阳,110016
2. 中国科学院上海药物研究所,上海,201203 |
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| 摘 要： | 目的:建立测定曲美他嗪与人血浆蛋白结合率的高效液相色谱法(HPLC),测定曲美他嗪在人血浆中的蛋白结合率。方法:采用平衡透析法,结合HPLC测定曲美他嗪在人血浆中的蛋白结合率。结果:低、中、高3个浓度下,曲美他嗪的血浆蛋白结合率分别为14.7%,16.2%和15.5%。结论:本方法灵敏度高,重现性好,操作简单,能满足生物样品分析的要求。曲美他嗪与血浆蛋白结合率较低。
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| 关 键 词： | 曲美他嗪 血浆蛋白结合率 平衡透析法 高效液相色谱法 |
Determination of Binding Rate of Trimetazidine and Human Plasma Protein |
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| LV Jiang,QI Ying-jie,BI Kai-shun,GUO De-an,CHEN Xiao-hui.Determination of Binding Rate of Trimetazidine and Human Plasma Protein[J].Progress in Modern Biomedicine,2010,10(24). |
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| Authors: | LV Jiang QI Ying-jie BI Kai-shun GUO De-an CHEN Xiao-hui |
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| Institution: | LV Jiang1,QI Ying-jie1,BI Kai-shun1,GUO De-an2,CHEN Xiao-hui1(1 School of Pharmacy,Shenyang Pharmaceutical University,Shenyang Liaoning 110016,China,2 Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai Liaoning 201203,China) |
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| Abstract: | Objective: To develop an HPLC method to determine the trimetazidine in human plasma and to analysise the plasma protein binding rate of trimetazidine.Methods: The equilibrium dialysis combined with HPLC was carried out to determine of the plasma concentration and plasma protein binding rate of trimetazidine.Result: Human plasma protein binding rates were 14.7 %,16.2 % and 15.5 % when the trimetazidines were low,middle and high,respectively.Conclution: The method of equilibrium with HPLC had the low binding ... |
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| Keywords: | Trimetazidine Plasma protein binding rate Equilibrium dialysis High performance liquid chromatography |
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