Active specific immunotherapy of guinea pigs with visceral tumor implants |
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Authors: | Eliyahu Yarkoni James T Hunter Saraswati Sukumar and Herbert J Rapp |
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Institution: | (1) Laboratory of Immunobiology, National Cancer Institute, 20205 Bethesda, MD, USA;(2) Present address: The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel;(3) Present address: The Stehlin Foundation for Cancer Research, 777 Saint Joseph Professional Building, 77002 Houston, Texas, USA |
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Abstract: | Summary Guinea pigs, each with established, 7-day-old, syngeneic visceral micrometastases of line 10 tumor implanted intravenously, were immunized by intradermal inoculations into several sites of a mixture of irradiated line 10 cells and an emulsion containing heat-killed BCG or Mycobacterium phlei bacilli. This treatment led to survival of 72 of 80 treated animals (90%). Therapeutic effectiveness depended on the dose of mycobacteria and on that of irradiated tumor cells. Animals treated by intradermal injection of mycobacteria attached to oil droplets alone or with irradiated tumor cells alone, all died with multiple foci of pulmonary tumor. |
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