Conformational analysis of a covalently cross-linked Watson-Crick base pair model |
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Authors: | Jensen Erik A Allen Benjamin D Kishi Yoshito O'Leary Daniel J |
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Institution: | Department of Chemistry, Pomona College, 645 North College Avenue, Claremont, CA 91711, USA. |
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Abstract: | Low-temperature NMR experiments and molecular modeling have been used to characterize the conformational behavior of a covalently cross-linked DNA base pair model. The data suggest that Watson-Crick or reverse Watson-Crick hydrogen bonding geometries have similar energies and can interconvert at low temperatures. This low-temperature process involves rotation about the crosslink CH(2)C(5') (psi) carbon-carbon bond, which is energetically preferred over the alternate CH(2)N(3) (phi) carbon-nitrogen bond rotation. |
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