Genomic structure of the human ezrin gene |
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| Authors: | P. Majander-Nordenswan Markku Sainio Ossi Turunen Juha Jääskeläinen Olli Carpén Juha Kere Antti Vaheri |
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| Affiliation: | (1) Department of Virology, Haartman Institute, University of Helsinki, PO Box 21, FIN-00014 Helsinki, Finland e-mail: paivi.majander-nordenswan@helsinki.fi, Tel.: +358-9-19126517, Fax: +358-9-19126675, FI;(2) Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland, FI;(3) Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland, FI;(4) Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland, FI |
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| Abstract: | The ERM proteins, ezrin, radixin, and moesin, act as linkers between the plasma membrane and actin cytoskeleton. They are involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures, and are highly homologous, both in protein sequence and in functional activity, with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. We report here the genomic structure and intron junction sequences of the human ezrin gene. Ezrin consists of 13 exons and spans approximately 24 kb genomic DNA. The coding parts of the exons range in size from 12 bp to 275 bp and the introns from 182 bp to 7 kb. The genomic structures of ezrin and moesin are highly conserved, suggesting their recent divergence. Radiation hybrid mapping has refined the location of ezrin to the interval between D6S442 and D6S281. Received: 1 June 1998 / Accepted: 25 August 1998 |
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