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Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase |
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| Authors: | Xie Yuli Liu Yidong Gong Gangli Rinderspacher Alison Deng Shi-Xian Smith Deborah H Toebben Udo Tzilianos Effie Branden Lars Vidović Dusica Chung Caty Schürer Stephan Tautz Lutz Landry Donald W |
| Institution: | aDepartment of Medicine, Columbia University, 650 W 168th Street, BB 1029, New York, NY 10032, USA bDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA cScientific Computing, The Scripps Research Institute, Jupiter, FL 33458, USA dInfectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA |
| Abstract: | We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency. |
| Keywords: | Thiazolidine Lyp pTyr mimics Salicylate |
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