Chronic treatment with bromocriptine induces behavioral supersensitivity in rats |
| |
| Authors: | M N Hassan D Higgins M Traub S Fahn |
| |
| Affiliation: | 1. Department of Neurology with Experimental Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany;2. Berlin Institute of Health, Germany;3. Technische Universität Berlin, Control Systems Group, 10587 Berlin, Germany;4. Department of Neurology, University Hospital Würzburg, Josef-Schneider-Straße 11, 97080 Würzburg, Germany;5. Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Germany;6. DZHK (German Center for Cardiovascular Research), Berlin Site, Germany;7. DZNE (German Center for Neurodegenerative Disease), Berlin Site, Germany;8. Parkinson Institute Milan, ASST Pini-CTO, Milano, Italy;9. Institute of Clinical Neurobiology, University Hospital Würzburg, Versbacher Straße 5, 97078 Würzburg, Germany;10. Center for Mental Health, University Hospital Würzburg, Margarete-Höppel-Platz 1, 97080 Würzburg, Germany;1. Laboratory of Chemical Neuroanatomy, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil;2. Center for Neuroscience and Behavior, Institute of Psychology, University of Sao Paulo, Sao Paulo, Brazil |
| |
| Abstract: | Chronic treatment of rotating rats with equipotent doses of the dopamine (DA) agonists apomorphine (APO), 3-(3,4-dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide (DPPP) and bromocriptine (BRO) for four weeks resulted in marked differences in rotational activity following acute administration of these agonists. Whereas chronic treatment with APO and DPPP failed to produce any significant changes in agonist-induced rotational behavior, chronic BRO treatment induced a progressive increase in rotational activity up to a mean 200% increase over controls at four weeks. These findings may, in part, explain the long-term clinical efficacy of bromocriptine in patients with Parkinson's disease. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
