Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. |
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| Authors: | F T van Amsterdam A Roveri M Maiorino E Ratti F Ursini |
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| Affiliation: | Glaxo Research Laboratories, Verona, Italy. |
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| Abstract: | Lacidipine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in a series of tests that consider specific radical species. A direct quenching of several radical species could be measured. Moreover, in biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E. |
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