| Abstract: | The mitochondria isolated from transplantable chicken hepatomatous growth induced by MC-29 virus were deficient in glutamate dehydrogenase. Oxypolarographic tests showed that glutamate oxidation in the tumor mitochondria was initiated via transamination, while glutamate was deaminated by glutamate dehydrogenase in liver mitochondria to supply adenosine triphosphate. Prominent glutamate oxidation and transformation-linked low glutamine synthetase activity may be favorable to the bioenergetics of this fast-growing tumor. |
